Strain-Specific Manifestation of Lupus-like Systemic Autoimmunity Caused byZap70Mutation
نویسندگان
چکیده
منابع مشابه
Hematologic manifestation of systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. The most common hematologic finding is anemia, leukopenia, thrombocytopenia and secondary antiphospholipid syndrome with recurrent abortion and thrombosis. The autoimmune fibrosis of bone marrow is another manifestation of autoimmune disease especially SLE, that must be correctly differentiated from primary myelofibrosis.
متن کاملClinical and preclinical manifestation of systemic lupus erythmatous
Introduction: Systemic lupus erythmatous (SLE) is a disease of unknown etiology with wide variety of clinical and immunological features. Our objective was to describe the clinical manifestation and laboratory data in Iranian male patients. Methods: 2279 patients were entered in a cross sectional study. The data were collected from rheumatologic research center in Shariati hospital of Teh...
متن کاملLupus nephropathy as the initial manifestation of systemic lupus erythematosus.
The present report documents the occurrence of lupus nephropathy as the sole initial manifestation of systemic lupus erythematosus (SLE). Despite the absence of initial systemic signs characteristic of SLE, the diagnosis was confirmed on the basis of the renal histopathologic features and serological studies. Subsequent follow-up demonstrated systemic features of the disease in each of the four...
متن کاملSystemic autoimmunity in systemic lupus erythematosus: handling of self-antigens
Our understanding of the pathogenesis mechanisms leading to lupus has been augmented by the analysis of several diff erent murine models over the past four decades. Various mouse models of spontaneous lupus have been employed in an eff ort to understand the cellular and genetic mechanisms behind induction of systemic lupus erythematosus (SLE). Th e classic models of spontaneous lupus include th...
متن کاملAtherosclerosis, autoimmunity, and systemic lupus erythematosus.
Atherosclerosis can be considered a chronic inflammatory condition of the vessel wall. Fatty streaks, the earliest morphological lesions of atherosclerosis, are caused by lipids (primarily of cholesteryl esters) accumulated within the macrophages (foam cells) and smooth muscle cells in the intimal layer. These lesions progress into atherosclerotic plaques containing extracellular matrix compone...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2019
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1801159